Preclinical Evaluation of Scorzonera sp. Root Extracts and Major Compounds Against Acute Hepatotoxicity Induced by Carbon Tetrachloride
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Hepatoprotective and Antioxidant Effects of Eupatorium ayapana against Carbon Tetrachloride Induced Hepatotoxicity in Rats
The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the methanol extract of Eupatorium ayapana (MEEA) (Family- Asteraceae) leaves in Wistar albino rats. The different groups of animals were administered with carbon tetrachloride (CCl4) at 72 h interval. The MEEA at 100, 200 and 300 mg/kg and silymarin 25 mg/kg were administered to the CCl4 treated ...
متن کاملEffect of propolis extract on acute carbon tetrachloride induced hepatotoxicity.
Ethanolic extract of propolis was administered to rats intoxicated by carbon tetrachloride. Administration of bolus dose of CCl4 (1.5 ml/kg, ip) resulted in elevation of serum transaminases and serum alkaline phosphatase activities. Levels of hepatic lipid peroxidation were significantly increased. On the contrary, there was significant decrease in hepatic reduced glutathione level. The propoli...
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Objective: The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Male Wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4), R. canina 250, 500, and 750 mg/kg + CCl4 and R. canina ...
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The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl4) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl4 recorded significant elevation in plasma markers of hepatic injury, alteration in hepatic antioxidant status and histopathol...
متن کاملMechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites.
CCl4-induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent binding of CCl4 metabolites to cell components and/or peroxidative damage as the cause of injury. (1) Covalent binding of 14C-labeled metabolites was detected in hepatocytes immediately after exposure to CCl4. (2) Low oxygen partial pressure increased the reductive meta...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2017
ISSN: 0250-474X
DOI: 10.4172/pharmaceutical-sciences.1000284